Teenage substance use is often driven by convenience. Adolescents misuse substances that are easy to get or easy to hide. Some of the most common drugs teens abuse include alcohol, marijuana, prescription medications and over-the-counter substances.
Alcohol
Alcohol is the most commonly abused substance by teens, according to the Office of Population Affairs. Because drinking is largely considered socially acceptable once someone is of legal age, teens tend to view alcohol as relatively harmless. Nearly half of high school seniors in the United States reported drinking alcohol within the last year, according to the National Institutes of Health.
The National Institute on Alcohol Abuse and Alcoholism notes that teens are more likely to binge drink because their impulse control hasn’t fully developed. Binge drinking increases the risk of alcohol addiction in people of any age, but the teenage brain is even more susceptible to addiction.
Marijuana
As of 2026, 40 U.S. states have legalized marijuana for medicinal use, and 24 allow recreational use, according to the American Nonsmokers’ Rights Foundation. The decriminalization of cannabis has led to an overall change in the social perception of marijuana use, which may make teens think that smoking weed doesn’t carry risks.
Around 25% of high school seniors reported using marijuana in the past year. Early marijuana use is linked to marijuana addiction in adulthood, and using marijuana may also increase the likelihood of a teen experimenting with other substances.
Prescription Medications
Misuse of prescription narcotics, such as OxyContin, and benzodiazepines, such as Xanax, is especially common among teens. According to the Centers for Disease Control, 14% of high school students have abused prescription opioids. Many teens take prescription drugs because they feel they’re a safer choice than using illicit drugs. But the truth is that these medications carry a significant risk of forming a prescription drug addiction and other health complications.
Over-the-Counter Substances
Misuse of over-the-counter substances, such as cough syrup, is especially common in teens because these substances are cheap and easy to get legally. Teens may mix large amounts of cough syrup with soda or other drinks to get a high. Some students may abuse inhalants, which involves huffing aerosol cans, such as paint, hairspray and even whipped cream cans.